Yale University · GeneticsWang Spatial Lab
Siyuan Wang · New Haven, Connecticut
Research Focus
Dr. Siyuan Wang's lab at Yale University focuses on understanding how the spatial organization of DNA and RNA within cells influences gene function and protein production. By developing advanced imaging and genetic screening technologies, the lab aims to identify regulators that control this spatial arrangement, leading to new insights in molecular biology relevant to health and disease.
CRISPR3D genomespatial omicsgenetic screeningtranscriptomicschromatin organizationhigh-content imagingmulti-omic
Research Aims
3AIM 01Develop a large-scale screening platform for spatial omics techniques.
AIM 02Create multimodal detection methods for 3D nucleome regulators.
AIM 03Establish integrative methods for large-scale screening of spatial transcriptome phenotypes.
Skills the Lab Values
CRISPR screeninghigh-content imagingcell cultureRNA sequencingchromatin mappingdata analysisin situ hybridizationmicroscopy
Output against the department
Publications170top 47% of dept.121st of 259
this lab
most publishedleast published
Citations9.0kbottom 46% of dept.139th of 259
this lab
most citedleast cited
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