WMCWeill Medical College of Cornell University · Biochemistry
Mcgraw Metabolism Lab
Timothy E Mcgraw · New York, New York
Research Focus
Dr. Timothy McGraw's lab focuses on understanding how incretin hormones, specifically GIP and GLP-1, control metabolism in the body. These hormones are important for regulating insulin secretion and sensitivity, with potential applications in treating diabetes, heart disease, and even neurodegenerative disorders. The lab develops mouse models to explore the molecular mechanisms of GIP receptor signaling, which could lead to improved therapies targeting these hormones.
incretin hormonesGIP receptorinsulin sensitivitymetabolic controlcancer therapiesneurodegenerative diseasesmouse modelsquantitative microscopyRNA sequencing
Research Aims
5AIM 01Investigate the signaling mechanisms of GIP receptors in pancreatic beta-cells.
AIM 02Use mouse models to compare metabolic outcomes between different GIP receptor variants.
AIM 03Profile gene expression changes in islets using RNA sequencing.
AIM 04Analyze the effects of GIP on insulin secretion and sensitivity in vivo.
AIM 05Explore the role of biased signaling in the metabolic differences observed between the GIP receptor variants.
Skills the Lab Values
mouse modelsquantitative microscopyRNA sequencingcell cultureinsulin secretion assaysglucose tolerance testsbiochemical assaysmolecular biology techniquesflow cytometry
Output against the department
Publications155bottom 44% of dept.226th of 402
this lab
most publishedleast published
Citations16ktop 29% of dept.118th of 402
this lab
most citedleast cited
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