Columbia University in the City of New York · Biochemistry · BiologyThe Splicing Nexus
Chaolin Zhang · New York, New York
Research Focus
Chaolin Zhang's research lab at Columbia University focuses on understanding how RNA molecules and their binding proteins regulate gene expression, especially in the brain. They study alternative splicing, a process that generates diverse proteins from a single gene, which is crucial for the function of different neuronal cell types. Their work aims to map regulatory elements that control this splicing and investigate how alterations in these processes can lead to neurological disorders and other diseases.
alternative splicingRNA-binding proteinsgene regulationneuronal diversitydisease mechanisms
Research Aims
5AIM 01Map splicing-regulatory elements across the human genome.
AIM 02Characterize RNA regulatory networks in neuronal cell types.
AIM 03Decode protein-RNA interactions relevant to gene expression.
AIM 04Investigate the role of splicing in neuronal function.
AIM 05Develop therapeutic strategies targeting splicing abnormalities.
Skills the Lab Values
RNA sequencingPCRcell culturecomputational modelinggenomic data analysisCRISPRanimal modelsbioinformaticssingle-cell RNA sequencing
Output against the department
Publications113bottom 37% of dept.907th of 1,433
this lab
most publishedleast published
Citations12ktop 32% of dept.463rd of 1,433
this lab
most citedleast cited
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