University of Notre Dame · EngineeringThe Glucose Guardian Lab
Matthew Webber · Notre Dame, Indiana
Research Focus
Dr. Matthew Webber's lab at the University of Notre Dame focuses on developing innovative insulin therapies for diabetes management. They aim to create a once-weekly insulin formulation that responds to blood glucose levels, making it easier for patients to control their diabetes. By combining advanced materials and chemical modifications, the lab seeks to improve patient adherence and enhance therapeutic outcomes while minimizing risks associated with insulin therapy.
insulin therapyglucose-responsive insulindendrimer carriersdiabetes managementonce-weekly dosingtherapeutic adherencechemical modificationbiocompatibilitydrug deliverypharmacokinetics
Research Aims
5AIM 01Develop a once-weekly insulin formulation that dynamically responds to glucose levels.
AIM 02Explore new linker and conjugation strategies to enhance insulin potency.
AIM 03Investigate biocompatible dendrimer carriers for insulin delivery.
AIM 04Validate the efficacy of insulin formulations in diabetic rodent models.
AIM 05Translate technology into a viable treatment option using a diabetic swine model.
Skills the Lab Values
cell culturedendrimer synthesischemical modification techniquesin vivo modelingdrug formulationbiocompatibility assessmentglucose clamp techniquepharmacokinetic studiesdata analysisnanoengineering
Output against the department
Publications199top 48% of dept.133rd of 278
this lab
most publishedleast published
Citations16ktop 25% of dept.69th of 278
this lab
most citedleast cited
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