Icahn School of Medicine at Mount Sinai · GeneticsZhang Neurobiology Lab
Bin Zhang · New York, New York
Research Focus
The research lab led by Dr. Bin Zhang at the Icahn School of Medicine focuses on understanding Alzheimer's disease (AD) through the lens of cellular aging and genetic factors. By investigating the roles of senescent cells and the interaction between sex and the APOE gene, the lab aims to uncover new therapeutic targets for AD. Their innovative approaches include advanced single-cell sequencing techniques and multi-omics data analysis, enabling them to create personalized strategies for AD treatment and prevention.
Alzheimer's DiseasesenescenceAPOEmulti-omicssingle-cell RNA-seqtherapeuticsneurodegenerationdrug repositioningmolecular subtypessex differences
Research Aims
4AIM 01Investigate the characteristics of senescent cells in various Alzheimer's disease subtypes.
AIM 02Analyze the interplay between sex and the APOE genotype in Alzheimer's disease.
AIM 03Develop novel therapeutics targeting brain senescence.
AIM 04Create integrative network models to identify molecular drivers of Alzheimer's disease.
Skills the Lab Values
single-cell RNA sequencingmulti-omics analysisATAC-seqbioinformaticsspatial transcriptomicsmachine learningdrug screeningin vivo experimentscell culturedata analysis
Output against the department
Publications590top 10% of dept.25th of 259
this lab
most publishedleast published
Citations50ktop 12% of dept.32nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.