University of California-Santa Cruz · BiochemistryChen Neurodevelopment Lab
Bin Chen · Santa Cruz, California
Research Focus
Dr. Bin Chen's lab at UC Santa Cruz focuses on understanding how neural stem cells in the brain develop into various cell types needed for proper brain function. The research aims to uncover the mechanisms behind how these stem cells switch from producing neurons to producing supporting glial cells during brain development. This work is crucial for understanding developmental disorders and may contribute to better treatments for brain-related diseases.
neural stem cellscortical developmentlineage progressionastrocytesoligodendrocytesneurodevelopmental disordersmolecular mechanismsmouse geneticssingle-cell RNA sequencingbrain circuits
Research Aims
3AIM 01Determine lineage segregation patterns among different cell types derived from cortical neural stem cells.
AIM 02Investigate the role of Shh signaling in astrocyte lineage specification.
AIM 03Uncover molecular mechanisms underlying the lineage switch in cortical radial glial cells.
Skills the Lab Values
mouse geneticsRNA sequencingsingle-cell RNA-seqChIP-seqATAC-seq4C technologiescell culturemolecular cloningflow cytometrygenetic analysis
Output against the department
Publications593top 7% of dept.27th of 402
this lab
most publishedleast published
Citations36ktop 7% of dept.29th of 402
this lab
most citedleast cited
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