Baylor College of Medicine · GeneticsOsteogenesis Imperfecta Research Lab
Yangjin Bae · Houston, Texas
Research Focus
Dr. Yangjin Bae's lab at Baylor College of Medicine focuses on understanding and treating Osteogenesis Imperfecta (OI), a brittle bone disorder caused by genetic mutations affecting collagen. The lab researches how targeting a signaling protein called TGF can improve bone health in OI patients, especially those who do not respond well to existing therapies. Their work aims to develop new and effective treatments that can enhance bone density and healing for people with varying severities of OI.
Osteogenesis ImperfectaTGF signalingbone healthcollagentherapeutic innovations
Research Aims
4AIM 01Investigate if TGF signaling is responsible for PTH insensitivity in OI
AIM 02Develop a bone-targeted anti-TGF antibody and determine its dose range for OI treatment
AIM 03Assess the effects of anti-TGF treatment on fracture healing in OI
AIM 04Explore how abnormal collagen affects TGF interaction and signaling in OI
Skills the Lab Values
cell culturemouse modelsbiomechanics testingclinical trialsantibody development
Output against the department
Publications38bottom 7% of dept.242nd of 259
this lab
most publishedleast published
Citations2.3kbottom 10% of dept.234th of 259
this lab
most citedleast cited
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