Thomas Jefferson University · PharmacologyBreast Cancer Resistance Research Lab
Hallgeir Rui · Philadelphia, Pennsylvania
Research Focus
Dr. Hallgeir Rui's lab at Thomas Jefferson University focuses on understanding the complex mechanisms behind breast cancer, particularly the aggressive forms that resist treatment. Their research seeks to uncover why certain breast cancers, especially those that are estrogen receptor-positive and have a mixed luminal-basal phenotype, become resistant to therapies. The lab aims to develop better diagnostic tools and new treatment strategies to improve outcomes for patients with these challenging cancers.
breast cancertherapy resistanceWNT signalingHer2 expressiondiagnostic biomarkers
Research Aims
3AIM 01Identify mechanisms of therapy resistance in aggressive breast cancer
AIM 02Develop improved diagnostic tools for breast cancer
AIM 03Explore new treatment strategies for latent metastases
Skills the Lab Values
cell cultureimmunofluorescencegene expression analysismouse modelstherapeutic screening
Output against the department
Publications440top 13% of dept.58th of 462
this lab
most publishedleast published
Citations9.6ktop 40% of dept.183rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.