University of Florida · Biomedical EngineeringHudalla Lab
Gregory Hudalla · Gainesville, Florida
Research Focus
Dr. Gregory Hudalla's lab focuses on developing new therapies to reduce inflammation in the body. The research aims to create synthetic assemblies of proteins that can effectively target and treat chronic inflammatory conditions without the side effects associated with traditional drugs. By engineering these protein assemblies, the lab hopes to improve how the immune system regulates inflammation, potentially aiding millions of people suffering from chronic inflammatory diseases.
anti-inflammatory therapiessynthetic proteinsgalectin-1galectin-3chronic inflammationimmunoregulationnanoassemblylocalized drug deliverybiomedical engineering
Research Aims
4AIM 01Develop synthetic multivalent assemblies of galectin-1 and galectin-3 to enhance anti-inflammatory potency.
AIM 02Evaluate the effectiveness of these constructs in suppressing local inflammation.
AIM 03Identify mechanisms of action of the new anti-inflammatory therapies using various signaling models.
AIM 04Establish pharmacokinetics and safety profiles of the protein assemblies in vivo.
Skills the Lab Values
protein engineeringcell culturein vivo imagingRNA sequencingELISAhistologybiochemical assaysactivity measurementdata analysis
Output against the department
Publications83bottom 12% of dept.521st of 595
this lab
most publishedleast published
Citations2.2kbottom 16% of dept.501st of 595
this lab
most citedleast cited
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