University of Michigan-Ann Arbor · Microbiology & ImmunologyOno Lab
Akira Ono · Ann Arbor, Michigan
Research Focus
Dr. Akira Ono's lab at the University of Michigan studies the HIV virus and how it infects host cells, particularly CD4+ T cells. They investigate the mechanisms of HIV assembly and entry into these immune cells, focusing on the roles of specific proteins and cellular processes that contribute to the infection cycle. Their research aims to identify new antiviral strategies to combat HIV by interfering with how the virus assembles and spreads within the body.
HIV-1MacropinocytosisViral AssemblyCD4+ T CellsEndocytosisAntiviral StrategiesGag ProteinViral EntryCell Membrane
Research Aims
4AIM 01Investigate how Gag protein localization affects HIV assembly at the plasma membrane.
AIM 02Determine the role of macropinocytosis in HIV-1 entry into CD4+ T cells.
AIM 03Identify interactions between viral proteins and host cellular components.
AIM 04Understand how Gag translation sites influence viral assembly and spread.
Skills the Lab Values
Cell CultureMicroscopyRNA AnalysisFlow CytometryProtein PurificationMolecular CloningTransfection TechniquesWestern BlottingViral Infection Models
Output against the department
Publications540top 5% of dept.24th of 486
this lab
most publishedleast published
Citations14ktop 28% of dept.137th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.