Washington University in St Louis · NeuroscienceTau Dynamics Lab
Chihiro Sato · Saint Louis, Missouri
Research Focus
Dr. Chihiro Sato's lab at Washington University focuses on understanding primary tauopathies, a group of brain disorders that include conditions like progressive supranuclear palsy and frontotemporal degeneration. The lab is investigating specific forms of tau proteins in cerebrospinal fluid that could serve as biomarkers to assist in the diagnosis and treatment of these diseases. By identifying changes in tau proteoforms during disease progression, their work aims to improve clinical trials and personalize medicine for patients suffering from these disorders.
tauopathiesAlzheimer's diseasebiomarkerscerebrospinal fluidneuropathologydisease progressiontau proteoformsclinical trialsneurodegenerative diseases
Research Aims
5AIM 01Identify specific tau proteoforms in cerebrospinal fluid that indicate primary tauopathies.
AIM 02Determine changes in tau proteoforms during the progression of the disease.
AIM 03Develop accurate diagnostic criteria for primary tauopathies.
AIM 04Facilitate clinical trial eligibility through biomarker identification.
AIM 05Contribute towards personalized medicine approaches for tauopathies.
Skills the Lab Values
Cerebrospinal fluid analysisMass spectrometryImmunohistochemistryBiomarker discoveryProtein analysisClinical trial designNeuroimaging techniquesStatistical analysisResearch methodology
Output against the department
Publications116bottom 41% of dept.398th of 671
this lab
most publishedleast published
Citations6.2kbottom 43% of dept.383rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.