University of North Carolina at Charlotte · ChemistryCopper Balance Laboratory
Eva Ge · Charlotte, North Carolina
Research Focus
Dr. Eva Ge's research focuses on understanding how a protein called CCS (Copper Chaperone for Superoxide Dismutase) regulates copper levels in cells. This is important because too much or too little copper can lead to serious diseases like cancer and neurodegeneration. The lab employs various techniques to study how the phosphorylation of CCS affects its ability to manage copper and maintain cellular health. By investigating these mechanisms, the lab aims to discover new treatments for diseases associated with copper imbalance.
Copper homeostasisPhosphorylationNeurodegenerative diseasesCancerMetallochaperones
Research Aims
3AIM 01Investigate how phosphorylation of serine 245 affects CCS's copper-binding properties.
AIM 02Characterize the impact of CCS phosphorylation in cellular models.
AIM 03Identify kinases and phosphatases that modify CCS's phosphorylation.
Skills the Lab Values
Protein chemistryBiochemical assaysCellular modelsSolid-phase peptide synthesisExperimental design
Output against the department
Publications23bottom 4% of dept.208th of 216
this lab
most publishedleast published
Citations3.4kbottom 23% of dept.166th of 216
this lab
most citedleast cited
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