The University of Texas Medical Branch at Galveston · NeuroscienceNeuronal DNA Repair and Integrity Unit
Partha S Sarkar · Galveston, Texas
Research Focus
Dr. Partha S. Sarkar's lab at the University of Texas Medical Branch in Galveston focuses on understanding how the huntingtin protein impacts DNA damage repair in neurons, especially in the context of Huntington's disease. They investigate the role of various proteins and complexes involved in repairing DNA double-strand breaks, which are critical for the health of neurons. Through their research, they aim to uncover mechanisms that could lead to new strategies for slowing down the progression of neurodegenerative diseases.
Huntington's diseaseDNA damage repairneuronal healthchromatin remodelinggenome integrity
Research Aims
3AIM 01Identify how mutant huntingtin alters the function of DNA repair complexes.
AIM 02Determine the functional consequences of disrupted DNA repair on neuronal health.
AIM 03Evaluate the impact of modulating protein complexes involved in DNA damage response.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysgenomic analysesprotein purification
Output against the department
Publications53bottom 12% of dept.589th of 671
this lab
most publishedleast published
Citations2.9kbottom 20% of dept.534th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.