Icahn School of Medicine at Mount Sinai · NeuroscienceWang Lab
Jun Wang · New York, New York
Research Focus
Dr. Jun Wang's lab at the Icahn School of Medicine is dedicated to understanding Alzheimer’s disease, especially its social behavior and neuropsychiatric symptoms. They explore how individual vulnerability to stress can affect these symptoms in mouse models, investigating ways to promote stress-resilience as a potential preventive strategy against Alzheimer's-related issues. The lab combines approaches from neuroscience to study the biological mechanisms behind stress and behavioral changes in the context of Alzheimer’s disease.
Alzheimer's diseaseneuropsychiatric symptomsstress resiliencemicrogliamouse modelsneurobiologybehavioral neurosciencechronic stressgene expression
Research Aims
5AIM 01Investigate the influence of stress vulnerability on neuropsychiatric symptoms in Alzheimer's disease models.
AIM 02Examine the role of microglia in stress response and behavioral changes in mice.
AIM 03Promote stress resilience to prevent the onset of Alzheimer's-related neuropsychiatric symptoms.
AIM 04Analyze sex differences in stress responses and neurobiological outcomes.
AIM 05Identify molecular targets for treating neuropsychiatric symptoms in Alzheimer's disease.
Skills the Lab Values
mouse modelsbehavioral analysiselectrophysiologygene expression analysischronic stress paradigmsdata collectioncognitive assessmentsmolecular techniquesneuroimaging