University of Nebraska Medical Center · BiochemistryMoorthy Glycobiology Lab
Moorthy P. Ponnusamy · Omaha, Nebraska
Research Focus
Dr. Moorthy P. Ponnusamy's lab at the University of Nebraska Medical Center focuses on understanding how specific sugar molecules on proteins, called truncated O-glycans, affect the spread of pancreatic cancer. They investigate how these sugar alterations influence cancer behavior and contribute to the aggressive nature of the disease. Their work aims to develop potential new treatments by manipulating these sugar structures.
pancreatic cancerO-glycansmetastasisglycobiologyC1GALT1
Research Aims
3AIM 01Investigate the impact of C1GALT1 expression on glycosylation in pancreatic cancer
AIM 02Elucidate how truncated O-glycans facilitate metastasis in pancreatic cancer
AIM 03Determine the in vivo impact of truncated O-glycans on cancer progression using knockout mouse models.
Skills the Lab Values
CRISPRcell culturemouse modelshistocytochemistrymolecular weight analysis
Output against the department
Publications265top 26% of dept.106th of 402
this lab
most publishedleast published
Citations7.8kbottom 42% of dept.232nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.