Clemson University · EngineeringDynamic State Oncology Lab
Marc R. Birtwistle · Clemson, South Carolina
Research Focus
Dr. Marc R. Birtwistle's lab focuses on understanding cancer drug resistance, particularly in glioblastoma, by studying how cancer cells change states dynamically. They aim to develop new therapy strategies that promote drug-sensitive states while minimizing drug resistance. The research combines computational modeling with advanced experimental techniques to predict responses to chemotherapy and identify effective treatment combinations.
cancer therapydrug resistanceglioblastomacell state networksepigeneticstumor microenvironmentcomputational modelingsingle cell RNA sequencingflow cytometry
Research Aims
4AIM 01Develop glioma cell state network models to understand drug responses.
AIM 02Determine how microenvironmental factors influence cell state networks in gliomas.
AIM 03Assess the response of glioma cell state networks to single chemotherapy drugs.
AIM 04Evaluate predicted combination therapies using in vitro models.
Skills the Lab Values
cell culture techniquesflow cytometrysingle cell RNA sequencingcomputational modelingexperimental designdata analysistumor chip systemsco-culture techniquesepigenetic analysis
Output against the department
Publications144bottom 35% of dept.180th of 278
this lab
most publishedleast published
Citations4.6kbottom 35% of dept.180th of 278
this lab
most citedleast cited
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