RUThe Rockefeller University · Biochemistry
Ribosome Assembly Research Lab
Sebastian Klinge · New York, New York
Research Focus
Dr. Sebastian Klinge's lab at Rockefeller University studies how ribosomes, the molecular machines responsible for protein synthesis, are assembled in cells. The lab focuses on understanding the complex process of ribosome assembly, particularly the early stages that occur in the nucleolus. By integrating advanced techniques like cryo-electron microscopy and AI-based tools, the lab aims to uncover the mechanisms involved in this critical process and how errors in ribosome assembly can lead to blood disorders known as ribosomopathies.
ribosome assemblybiochemical analysisAI in researchcryogenic electron microscopyRNA biology
Research Aims
5AIM 01Investigate the mechanisms of eukaryotic ribosome assembly.
AIM 02Explore transient assembly intermediates of ribosomal subunits.
AIM 03Uncover the co-transcriptional assembly events in the nucleolus.
AIM 04Study the link between ribosome assembly defects and human diseases.
AIM 05Develop novel AI-based tools for analyzing ribosome biogenesis.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)protein purificationmass spectrometrygenetic manipulationbiochemical assaysdata analysis with AI tools
Output against the department
Publications65bottom 11% of dept.355th of 402
this lab
most publishedleast published
Citations3.3kbottom 15% of dept.340th of 402
this lab
most citedleast cited
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