Columbia University in the City of New York · ChemistryGonzalez Translation Lab
Ruben L Gonzalez · New York, New York
Research Focus
Dr. Ruben Gonzalez's lab at Columbia University focuses on understanding how the ribosome, a vital cellular structure, translates messenger RNA (mRNA) into proteins. The research explores the structural dynamics and control mechanisms of translation in both bacteria and humans, aiming to uncover new ways to combat diseases linked to translation processes. The lab employs advanced techniques like single-molecule fluorescence and structural biology to study these intricate systems, with the hope of aiding in the development of novel antibiotics and therapeutics.
translationribosomeantibioticssingle-molecule fluorescenceprotein synthesis
Research Aims
5AIM 01Investigate the dynamics of the translation machinery during the initiation of protein synthesis.
AIM 02Understand how protein initiation factors affect ribosomal dynamics.
AIM 03Explore ribosomal frameshifting mechanisms for correcting mutations in mRNA.
AIM 04Study ribosome rescue processes to identify how translation machinery resolves issues during protein synthesis.
AIM 05Expand research to include eukaryotic-specific translation control mechanisms.
Skills the Lab Values
single-molecule fluorescencebiochemical assaysstructural biologyyeast in vitro translationantibiotic development
Output against the department
Publications173bottom 41% of dept.128th of 216
this lab
most publishedleast published
Citations5.8kbottom 40% of dept.130th of 216
this lab
most citedleast cited
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