University of Pittsburgh-Pittsburgh Campus · Mathematics & StatisticsThe Tumor Model Initiative
George C. Tseng · Pittsburgh, Pennsylvania
Research Focus
Dr. George C. Tseng's lab focuses on improving cancer research by developing methods to evaluate and select the best laboratory models that mimic real human tumors. Using advanced techniques like single-cell RNA sequencing, the lab aims to understand the diversity within tumors and how this affects treatment responses. Their work is crucial for advancing precision medicine and optimizing cancer therapies.
Cancer ModelsSingle-cell RNA SequencingDrug DiscoveryPrecision MedicineTumor MicroenvironmentSubclonal AnalysisOmicsPatient-derived XenograftsMachine Learning
Research Aims
3AIM 01Identify subclones and cell types in breast cancer.
AIM 02Assess congruence of cancer models with human tumors.
AIM 03Analyze changes in cancer model congruence over time.
Skills the Lab Values
Single-cell RNA sequencingBioinformaticsData analysisMolecular profilingStatistical modelingCancer model evaluationMachine learning techniquesAnimal modelsClinical annotation
Output against the department
Publications610top 10% of dept.13th of 131
this lab
most publishedleast published
Citations14ktop 32% of dept.42nd of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.