University of Illinois Chicago · BiochemistryFrolov Cell Biology Lab
Maxim Frolov · Chicago, Illinois
Research Focus
Maxim Frolov's research lab focuses on understanding how certain pathways in cells control their growth and specialization during animal development. Using the fruit fly Drosophila as a simpler model, the lab studies the Retinoblastoma (RB) and Hippo pathways and their roles in cell cycles and how they can lead to diseases when they malfunction. The goal is to gain insights that can potentially inform treatments for conditions like cancer and other growth-related diseases.
Retinoblastomacell proliferationdifferentiationDrosophilaHippo signalingtranscription factorsgenomicschromatinmetabolic regulation
Research Aims
5AIM 01Investigate the molecular mechanisms regulating cell proliferation through the RB pathway.
AIM 02Examine the role of E2F/Rbf in activating metabolic gene expression in skeletal muscle.
AIM 03Analyze the interactions between RB and Hippo signaling pathways.
AIM 04Identify upstream regulatory events in dedifferentiating photoreceptors using single cell techniques.
AIM 05Explore how dysregulations in these pathways can lead to developmental diseases.
Skills the Lab Values
PCRgenetic analysissingle cell genomicsepigenomicscell cultureRNA extractiongene expression analysisWestern blotDrosophila dissectionmuscle tissue analysis
Output against the department
Publications98bottom 24% of dept.306th of 402
this lab
most publishedleast published
Citations2.5kbottom 11% of dept.358th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.