Washington University in St Louis · Microbiology & ImmunologyKutluay Lab
Sebla B. Kutluay · Saint Louis, Missouri
Research Focus
Dr. Sebla B. Kutluay's lab at Washington University focuses on understanding how HIV-1 virus packages its genetic material, specifically looking at the roles of various RNA-binding proteins. The research investigates the mechanisms by which viral RNA is selected for packaging into new virus particles, aiming to uncover vulnerabilities that could be targeted for new antiviral therapies. This work contributes to our broader knowledge of viral replication and interactions between viruses and their host cells.
HIV-1RNA packagingvirus assemblyRNA-binding proteinsantiviral therapycellular defense mechanismsdimeric genomeGag protein
Research Aims
3AIM 01Investigate how adenosine-rich sequences influence HIV-1 gRNA packaging.
AIM 02Alter Gag protein affinity to examine effects on virus assembly.
AIM 03Study the role of antiviral proteins in hijacking viral RNA for their own use.
Skills the Lab Values
RNA isolationcell culturebiochemical assaysgenetic sequencingmolecular cloningprotein interaction studiesvirus manipulationflow cytometry
Output against the department
Publications58bottom 15% of dept.413th of 486
this lab
most publishedleast published
Citations2.6kbottom 16% of dept.407th of 486
this lab
most citedleast cited
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