University of Nevada-Las Vegas · ChemistryProtein Modification and Disease Dynamics Lab
Hui Zhang · Las Vegas, Nevada
Research Focus
Dr. Hui Zhang's lab at the University of Nevada Las Vegas focuses on understanding how specific proteins are modified by the addition of methyl groups to lysine residues, which can lead to their targeted destruction in the cell. This research is important because it links protein modification to various biological processes, including the regulation of stem cells and the development of cancers. By exploring the mechanisms behind this process, the lab aims to provide insights that could lead to new treatments for diseases associated with these pathways.
lysine methylationproteolysisubiquitin ligasesstem cellscancerepigenetic regulationprotein dynamicschromatin remodeling
Research Aims
3AIM 01Investigate the dynamic mechanisms of methylation and demethylation in protein proteolysis.
AIM 02Examine how ubiquitin ligase complexes work with methyl reader proteins on methylated substrates.
AIM 03Develop animal models to assess the relevance of methylation dependent proteolysis in diseases.
Skills the Lab Values
molecular cloningcell cultureanimal modelsWestern blottingimmunoprecipitationCRISPR gene editingRNA sequencingmass spectrometryproteomics
Output against the department
Publications436top 23% of dept.50th of 216
this lab
most publishedleast published
Citations16ktop 29% of dept.63rd of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.