University of California-San Diego · EngineeringEpigenetic Dynamics Laboratory
Sheng Zhong · La Jolla, California
Research Focus
Professor Sheng Zhong leads a lab at UC San Diego that focuses on understanding how cells make critical fate decisions during early embryonic development. Utilizing advanced techniques like fluorescence resonance energy transfer (FRET) biosensors, the lab investigates the dynamic changes in histone modifications and chromatin structures at single-cell levels. Their research aims to map out the complex epigenetic regulation that influences cell differentiation and gene expression, contributing to our understanding of developmental biology and regenerative medicine.
epigeneticsembryonic developmentFRET biosensorschromatin remodelinghistone modificationscell fate determination3D imagingRNA-genome interactionssingle-cell analysis
Research Aims
3AIM 01Investigate the spatiotemporal imaging of histone methylations in live single cells during embryonic development.
AIM 02Visualize locus-specific histone modifications occurring during embryonic development.
AIM 03Reprogram histone modifications at specific genomic loci to study their impact on cell differentiation.
Skills the Lab Values
FRETsingle-cell trackingchromatin immunoprecipitationlive-cell imagingRNA sequencingCRISPR technologyhigh-throughput screeninghistone modification assaysdata analysiscell culture
Output against the department
Publications183bottom 47% of dept.147th of 278
this lab
most publishedleast published
Citations13ktop 29% of dept.82nd of 278
this lab
most citedleast cited
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