University of California-San Francisco · BiologyThe Beta Cell Initiative
Julie Beth Sneddon · San Francisco, California
Research Focus
Dr. Julie Beth Sneddon's lab at UCSF focuses on understanding how human pancreatic cells develop, specifically the beta cells that produce insulin. By studying the unique aspects of human cell development, especially through new techniques like single-cell multi-omics, the lab aims to enhance methods for creating these insulin-producing cells from stem cells. This research is vital for developing effective treatments for diabetes, a disease that affects millions worldwide.
beta cell replacementstem cell therapyendocrine progenitorsdiabetes treatmenthuman pancreas developmentcell differentiationCRISPRinsulin productionmulti-omics
Research Aims
5AIM 01Elucidate the mechanisms of human endocrine lineage commitment.
AIM 02Characterize novel endocrine progenitor populations in developing human pancreas.
AIM 03Investigate the role of the FEV gene in beta cell development.
AIM 04Generate improved protocols for beta cell differentiation from human pluripotent stem cells.
AIM 05Identify optimal sub-populations of beta-like cells for transplantation.
Skills the Lab Values
CRISPR/Cas genome editingsingle-cell multi-omics analysiscell culture techniquesstem cell differentiation methodsgene expression profilingimmunostainingdata analysis in Rmicroscopy techniquesFACS sorting of cells
Output against the department
Publications45bottom 10% of dept.932nd of 1,033
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.672nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.