Icahn School of Medicine at Mount Sinai · BiologyThe Oocyte Odyssey Lab
Prashanth Rangan · New York, New York
Research Focus
Prashanth Rangan's lab focuses on understanding the important transition from germ cells to mature egg cells (oocytes), which is crucial for fertility. They use Drosophila, a type of fruit fly, as a model organism to explore how specific genes are silenced during this process to ensure the proper development of embryos. This research aims to uncover mechanisms that could lead to new insights into human infertility.
germ cellsoocyte developmentfertilitygene silencingDrosophiladevelopmental biologytotipotency
Research Aims
3AIM 01Investigate how gene expression changes during the germ cell-to-maternal transition.
AIM 02Identify the molecular mechanisms that target germ cell-specific genes for silencing.
AIM 03Understand the coordination between germ cell program silencing and oocyte specification.
Skills the Lab Values
RNA sequencinggene expression analysisDrosophila geneticsmolecular cloningcell cultureCRISPRimmunofluorescenceWestern blottingmicroscopy
Output against the department
Publications50bottom 12% of dept.908th of 1,033
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.936th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.