University of Pittsburgh-Pittsburgh Campus · BiologyThe GDAP1 Research Center
Kirill Kiselyov · Pittsburgh, Pennsylvania
Research Focus
Dr. Kirill Kiselyov's lab at the University of Pittsburgh focuses on understanding how neuronal cells die in Alzheimer's disease, particularly the role of a protein called GDAP1 in protecting against oxidative damage. The lab investigates the relationship between GDAP1 levels and a harmful compound known as 4-hydroxynonenal (4HNE), which accumulates in the brains of Alzheimer's patients. By studying cellular mechanisms in neuronal models, the lab aims to uncover potential therapeutic strategies for Alzheimer's disease.
Alzheimer's Diseaseoxidative stressmitochondrial functionGDAP14-hydroxynonenalneurodegenerationcellular redox balanceinduced neuronslipid peroxidation
Research Aims
2AIM 01Investigate the mechanism of GDAP1-mediated protection against oxidative damage.
AIM 02Examine the impact of reduced GDAP1 levels on mitochondrial function in neurons from Alzheimer's patients.
Skills the Lab Values
RNA sequencingcell cultureneuron modelingWestern blotproteomicsmolecular cloningmicroscopyoxidative stress assaysbiochemical assays
Output against the department
Publications150top 45% of dept.468th of 1,033
this lab
most publishedleast published
Citations8.2ktop 46% of dept.476th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.