Stanford University · BiologyLe Cong Genomics Lab
Le Cong · Stanford, California
Research Focus
Dr. Le Cong's lab at Stanford University focuses on developing cutting-edge gene editing technologies using human-derived enzymes. They aim to create a safe and efficient gene editing platform that allows researchers to make precise modifications in the genome without triggering negative immune responses. By utilizing a mitochondrial enzyme called Twinkle, the lab seeks to advance functional genomics and improve the study of various diseases, making it easier to visualize and manipulate proteins within cells.
gene editingCRISPRmitochondrial DNAfunctional genomicsprotein engineeringDNA repaircancer modelsstem cell applications
Research Aims
5AIM 01Develop a human-derived mitochondrial enzyme for gene editing.
AIM 02Optimize the Twinkle enzyme for improved editing efficiency.
AIM 03Validate the gene editing system in cancer and stem cell models.
AIM 04Facilitate functional screening of the proteome using the new technology.
AIM 05Investigate DNA repair mechanisms affecting gene editing outcomes.
Skills the Lab Values
PCRcell cultureelectroporationprotein engineeringWestern blotRNA sequencingmicroscopygenome editingorganoid modeling
Output against the department
Publications140top 49% of dept.508th of 1,033
this lab
most publishedleast published
Citations30ktop 11% of dept.115th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.