University of California-Berkeley · BiochemistryRetrotransposon Dynamics Lab
Kathleen Collins · Berkeley, California
Research Focus
Dr. Kathleen Collins' research lab at UC Berkeley focuses on understanding how certain enzymes, called non-LTR retrotransposons, insert DNA sequences into genomes. By studying the structure and function of these enzymes, her team aims to develop new methods for safely delivering transgenes into human cells, which could help treat genetic diseases. They use innovative techniques in biochemistry and molecular biology to explore the unique properties of these retrotransposons and their potential therapeutic applications.
non-LTR retrotransposonsgene deliverytransgene insertionbiochemistrymolecular biology
Research Aims
5AIM 01Investigate the mechanisms of non-LTR retrotransposon mobility.
AIM 02Develop the PRINT method for precise transgene insertion.
AIM 03Characterize protein structures involved in DNA repair processes.
AIM 04Examine the specificity of transgene integration sites.
AIM 05Explore the cellular mechanisms of transgene expression in ribosomal DNA loci.
Skills the Lab Values
RNA manipulationDNA insertion techniquescryoelectron microscopybiophysical assaysprotein-nucleic acid interactions
Output against the department
Publications184top 46% of dept.184th of 402
this lab
most publishedleast published
Citations14ktop 36% of dept.146th of 402
this lab
most citedleast cited
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