WMCWeill Medical College of Cornell University · Pharmacology
Buck Fertility Lab
Jochen Buck · New York, New York
Research Focus
Jochen Buck's lab at Weill Medical College focuses on understanding male fertility and sperm function, particularly during the process of capacitation, when sperm become capable of fertilizing an egg. The lab aims to develop non-hormonal contraceptive methods by designing inhibitors that target specific enzymes, with the goal of creating a safe and effective male birth control pill. This research not only addresses fundamental questions about male reproductive biology but also has significant implications for contraceptive development.
male contraceptionsperm capacitationadenylyl cyclasefertilitypharmacological inhibitorsmetabolismglucose utilizationpreclinical development
Research Aims
5AIM 01Develop non-hormonal contraceptive methods by targeting soluble adenylyl cyclase
AIM 02Investigate how sperm metabolize different nutrients during capacitation
AIM 03Identify selective inhibitors of adenylyl cyclase for male contraception
AIM 04Advance lead compounds into preclinical development for FDA approval
AIM 05Understand metabolic changes in sperm required for fertilization.
Skills the Lab Values
metabolite profilingmetabolic flux analysisin vitro fertilizationanimal modelspharmacokineticsdrug designPCRcell cultureWestern blot
Output against the department
Publications184top 48% of dept.224th of 462
this lab
most publishedleast published
Citations14ktop 28% of dept.131st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.