University of North Carolina at Chapel Hill · PharmacologyGenetic Therapeutics Lab
Paul B Watkins · Chapel Hill, North Carolina
Research Focus
Dr. Paul B. Watkins' lab at the University of North Carolina Chapel Hill focuses on understanding how genetic differences influence the effectiveness and safety of adeno-associated virus (AAV) gene therapies, particularly related to liver toxicity. By studying a diverse population of genetically different mice, the lab aims to uncover the underlying genetic factors that contribute to variability in how patients respond to AAV treatments. This research is intended to improve the design of safer and more effective gene therapies for genetic disorders that require liver targeting.
AAV gene therapyliver toxicitygenetic variabilitygene transfermice models
Research Aims
3AIM 01Elucidate the role of genetic factors in AAV liver toxicity and transduction efficiency.
AIM 02Identify non-genetic factors that influence susceptibility to AAV liver toxicity.
AIM 03Explore novel culture systems for studying AAV liver toxicity and transduction.
Skills the Lab Values
mouse modelsgenetic analysismolecular biology techniquesprotein analysiscell culture
Output against the department
Publications354top 20% of dept.91st of 462
this lab
most publishedleast published
Citations31ktop 8% of dept.37th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.