UMCUniversity of Massachusetts Chan Medical School · Biology
Triple Negative Breast Cancer Research Unit
Leslie M Shaw · Worcester, Massachusetts
Research Focus
Dr. Leslie Shaw's lab focuses on the role of a specific protein, IRS2, in regulating cell division in triple negative breast cancer (TNBC). The lab aims to understand how IRS2 contributes to cancer development and to explore new therapeutic strategies to combat this aggressive cancer subtype by targeting its unique vulnerabilities during cell division. Through their research, they hope to develop more effective treatments for patients with TNBC.
triple negative breast cancerIRS2spindle assembly checkpointcell divisiontherapeutic targets
Research Aims
3AIM 01Investigate how IRS2 regulates the spindle assembly checkpoint during cell division.
AIM 02Establish the molecular mechanisms of IRS2 in ensuring proper chromosomal segregation.
AIM 03Assess the potential of targeting IRS2-dependent functions in TNBC for therapeutic gain.
Skills the Lab Values
cell cultureWestern blotRNA sequencingimmunoprecipitationflow cytometry
Output against the department
Publications771top 3% of dept.27th of 1,033
this lab
most publishedleast published
Citations67ktop 2% of dept.24th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.