University of Chicago · BiochemistryPiccirilli Lab
Joseph Anthony Piccirilli · Chicago, Illinois
Research Focus
Dr. Joseph Piccirilli's lab at the University of Chicago focuses on understanding the role and structure of non-coding RNAs and their complexes with proteins and small molecules. They utilize innovative chemical and biochemical methods to investigate how these RNAs function in health and disease. By developing synthetic antibodies and studying catalytic RNAs, the lab aims to reveal critical insights into RNA structures and their biological significance.
non-coding RNARNA-protein complexesstructural biologyribozymescryoelectron microscopysynthetic antibodiesmacromolecular complexeschemical biologyRNA functiontranscriptome
Research Aims
5AIM 01Investigate the structure of non-coding RNAs and their protein complexes.
AIM 02Develop synthetic antibodies for RNA crystallization and structural studies.
AIM 03Elaborate mechanisms of RNA function focusing on ribozymes.
AIM 04Define the relationship between catalytic RNA structure and function.
AIM 05Enhance techniques for studying large and complex RNA molecules.
Skills the Lab Values
RNA extractioncrystallographycryoelectron microscopyprotein purificationbiochemical assay developmentbiophysical characterizationkinetic isotope effect analysisnucleotide analog synthesismolecular cloningdata analysis with Python
Output against the department
Publications255top 29% of dept.116th of 402
this lab
most publishedleast published
Citations9.6ktop 50% of dept.201st of 402
this lab
most citedleast cited
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