Icahn School of Medicine at Mount Sinai · GeneticsTissue Interaction and Mapping Lab
Guo-Cheng Yuan · New York, New York
Research Focus
Dr. Guo-Cheng Yuan's lab focuses on understanding the complex interactions between different cell types within tissue environments and how these interactions change during development, aging, and disease progression. The lab uses advanced spatial transcriptomics techniques to analyze the structural organization of tissues, specifically looking at the changes that occur during acute kidney injury. By developing new computational frameworks, they aim to produce powerful tools for researchers and clinicians to better investigate these vital areas of health and disease.
spatial transcriptomicstissue microenvironmentcell-cell interactionsacute kidney injurycomputational modelingepigenomicssystems biologyhigh-resolution mappingniche trajectories
Research Aims
3AIM 01Develop a new framework for constructing niche trajectories from spatial transcriptomic data.
AIM 02Extend the ONTraC framework for analyzing subcellular RNA localization patterns.
AIM 03Comprehensively characterize the tissue microenvironment organization in acute kidney injury models.
Skills the Lab Values
spatial transcriptomicscomputational modelingRNA localization analysisdata visualizationbioinformaticssystems biologyepigenomic techniqueshigh-throughput sequencingPython programming
Output against the department
Publications342top 24% of dept.61st of 259
this lab
most publishedleast published
Citations29ktop 20% of dept.52nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.