Tufts University · BiochemistryStrle Lab
Klemen Strle · Medford, Massachusetts
Research Focus
Dr. Klemen Strle's lab focuses on understanding Lyme disease, particularly why it affects people differently. They research the role of specific microbial proteins in causing excessive inflammation, which can lead to severe symptoms and complications. By studying these proteins in both human samples and mouse models, they aim to identify potential biomarkers for patients at risk of more severe disease and develop better treatment strategies.
Lyme diseaseBorrelia burgdorferiinflammationimmune responsebiomarkersantibiotic resistanceautoimmunitygene expressionprotein function
Research Aims
5AIM 01Determine the inflammatory capacity of specific Borrelia lipoproteins in vitro
AIM 02Evaluate the impact of Borrelia strains on arthritis severity in mouse models
AIM 03Characterize immune responses in Lyme disease patients
AIM 04Identify new Borrelia determinants of immunity and virulence
AIM 05Develop potential diagnostic approaches for severe Lyme disease.
Skills the Lab Values
cell culturemouse modelsgenetic engineeringWestern blotbioinformaticsPCRGWASimmunological assaysanimal handling
Output against the department
Publications123bottom 34% of dept.266th of 402
this lab
most publishedleast published
Citations5.1kbottom 30% of dept.283rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.