UTHThe University of Texas Health Science Center at Houston · Neuroscience
Sheikh Lab
Kazim A Sheikh · Houston, Texas
Research Focus
Dr. Kazim Sheikh's lab at the University of Texas Health Science Center focuses on understanding and treating Guillain-Barré syndrome (GBS), an autoimmune condition that affects peripheral nerves. The lab investigates how to modulate immune responses, specifically targeting macrophages which contribute to nerve injury. Using animal models, they explore new therapeutic strategies that could improve outcomes for GBS patients who currently face limited treatment options.
Guillain-Barré syndromeautoimmunitymacrophagesCSF1R signalingneuroinflammationperipheral nerve injuryimmunotherapy
Research Aims
3AIM 01Test the effectiveness of CSF1R blockade in animal models of GBS.
AIM 02Investigate the role of CSF1R signaling in nerve injury and macrophage infiltration.
AIM 03Validate expression of key inflammatory markers in human nerve samples affected by GBS.
Skills the Lab Values
animal modelscell culturebone marrow chimerasantibody neutralizationsmall molecule inhibitorsco-culture techniquesimmunohistochemistryflow cytometryin situ hybridization
Output against the department
Publications143bottom 49% of dept.339th of 671
this lab
most publishedleast published
Citations5.6kbottom 40% of dept.405th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.