Columbia University in the City of New York · PharmacologyYu Proteomics Lab
Yonghao Yu · New York, New York
Research Focus
Dr. Yonghao Yu's lab focuses on studying a specific protein modification called poly-ADP-ribosylation, which plays a critical role in how cells respond to stress and may be linked to neurodegenerative diseases like ALS and frontotemporal dementia. By using advanced techniques in mass spectrometry and bioinformatics, the lab aims to understand how this modification contributes to disease processes and potentially identify new therapeutic targets for treatment.
poly-ADP-ribosylationALSfrontotemporal dementiamass spectrometryproteomics
Research Aims
3AIM 01Define the global PARylation landscape in C9ORF72-ALS/FTD.
AIM 02Generate global protein expression profiles of C9ORF72-ALS/FTD induced pluripotent stem cell-derived neurons.
AIM 03Identify functionally important PARylated proteins and understand their roles in neurodegeneration.
Skills the Lab Values
mass spectrometrybioinformaticscell cultureprotein extractionquantitative proteomicsbiochemical assaysinduced pluripotent stem cellsdata analysisprotein quantification
Output against the department
Publications559top 10% of dept.44th of 462
this lab
most publishedleast published
Citations30ktop 10% of dept.44th of 462
this lab
most citedleast cited
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