University of Minnesota-Twin Cities · Biomedical EngineeringSachs Neuroimmunology Lab
Jonathan N Sachs · Minneapolis, Minnesota
Research Focus
Dr. Jonathan N Sachs' lab at the University of Minnesota focuses on innovative cell therapies to tackle neurodegenerative diseases such as Alzheimer's. By engineering macrophages from human stem cells, they aim to enhance the body’s ability to clear out damaging proteins and reduce inflammation in the brain. Their research integrates advanced genetic engineering techniques to create immune cells that can effectively target and manage Alzheimer's pathology.
neurodegenerationmacrophagescell therapyAlzheimer's diseasegenetic engineeringimmunotherapyinflammationiPSCchimeric antigen receptortau pathology
Research Aims
5AIM 01Develop human iPSC-derived macrophages that can target tau protein in Alzheimer's disease.
AIM 02Engineer macrophages to be unresponsive to inflammatory signals associated with disease.
AIM 03Evaluate the effectiveness of chimeric antigen receptor designs in modulating Alzheimer’s pathology.
AIM 04Implement a scalable process for producing genetically modified immune cells.
AIM 05Investigate the role of macrophages in the central nervous system in relation to neurodegeneration.
Skills the Lab Values
CRISPRcell culturehuman induced pluripotent stem cells (iPSC)in vitro assaysgenetic engineering techniquesflow cytometrymultiplex base editingimmunohistochemistryprotein purificationbiochemical assays
Output against the department
Publications152bottom 33% of dept.396th of 595
this lab
most publishedleast published
Citations4.8kbottom 36% of dept.378th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.