Baylor College of Medicine · GeneticsAlzheimer's Mechanisms and Therapeutics Lab
Hui Zheng · Houston, Texas
Research Focus
Dr. Hui Zheng's lab at Baylor College of Medicine focuses on understanding the biological mechanisms behind Alzheimer's Disease (AD), particularly the roles of lipid metabolism and immune response in the brain. Researchers investigate how certain enzymes and pathways affect neuroinflammation and cognitive decline in AD. The lab's work aims to identify potential therapeutic targets to improve treatment options for Alzheimer's patients.
Alzheimer's Diseaseneuroinflammationmicroglialipid metabolismcomplement pathwaysEH inhibitionbrain agingcell communicationastrocytescognitive function
Research Aims
5AIM 01Investigation of how soluble epoxide hydrolase affects lipid signaling in Alzheimer's disease.
AIM 02Examine the role of microglia in response to amyloid pathology in AD models.
AIM 03Identify new potential therapeutic targets in the complement signaling pathway.
AIM 04Assess the impact of astrocytic metabolism on neuroinflammation in AD.
AIM 05Characterize cell-type specific changes in arachidonic acid metabolism during aging.
Skills the Lab Values
PCRcell culturemouse modelsgenetic analysislipidomicsgene expression profilingflow cytometryWestern blotimmunohistochemistryneurobehavioral testing
Output against the department
Publications213top 39% of dept.101st of 259
this lab
most publishedleast published
Citations23ktop 24% of dept.62nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.