Dixon Lab
Rose Ellen Dixon · Davis, California
University of California-Davis · Physiology
Research focus
Dr. Rose Ellen Dixon's lab focuses on understanding how aging affects heart function and the mechanisms behind cardiovascular diseases. The research investigates how cellular structures in heart cells malfunction as people age, leading to problems like diastolic dysfunction. By finding out how certain proteins and lipids behave in aging heart cells, the lab aims to uncover new ways to maintain heart health and improve the quality of life for older adults.
cardiac agingendosomal traffickingCaV1.2 channelsPIP2 metabolismdiastolic dysfunctioncardiomyocytelipid regulationcardiac functionAlzheimer's diseasecardiovascular health
Research aims
3AIM 01Investigate age-associated changes in endosomal trafficking in cardiomyocytes.
AIM 02Analyze the effects of altered PIP2 metabolism on cardiac function in aging hearts.
AIM 03Develop strategies to restore normal endosomal function in aged heart cells.
Skills the lab values
cell culturelive-cell imaginglipid mass spectrometryWestern blotelectrophysiologyimmunofluorescenceproteomicsmolecular cloningendocytosis assaysanimal models
Output against the department
88publicationsbottom 22% of the department223rd of 286
most publishedleast published
1.9kcitationsbottom 10% of the department257th of 286
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. Position on each rail is this lab's rank, not its distance from the top: a department runs from one paper to tens of thousands, so rank is the only comparison that stays readable across it.