Wayne State University · BiochemistryNeutrophil Aging and Immunity Lab
Marta Rodriguez Garcia · Detroit, Michigan
Research Focus
Dr. Marta Rodriguez Garcia's lab focuses on understanding how aging affects the immune response in the female genital tract (FGT), specifically through the role of neutrophils in preventing infections. The research aims to uncover the mechanisms by which neutrophils provide protection against sexually transmitted infections and how these mechanisms change in older women. By employing advanced techniques like single-cell sequencing and tissue spatial transcriptomics, the lab seeks to develop new strategies for enhancing mucosal immunity in aging populations.
neutrophilsagingfemale genital tractsexually transmitted infectionsimmune defensemulti-omicstissue inflammationmucosal protection
Research Aims
5AIM 01Investigate how aging alters neutrophil function in the female genital tract.
AIM 02Identify the specific neutrophil subsets involved in defense against infections.
AIM 03Determine the spatial distribution of neutrophils in the genital tract tissue of younger and older women.
AIM 04Explore the impact of aging on neutrophil-mediated tissue inflammation.
AIM 05Develop strategies for enhancing mucosal immunity in older women.
Skills the Lab Values
multi-omics technologiessingle-cell RNA sequencingtissue spatial transcriptomicsin vitro functional assaysflow cytometrycell culturehistological analysisdata analysis in R or Python
Output against the department
Publications94bottom 22% of dept.313th of 402
this lab
most publishedleast published
Citations2.6kbottom 13% of dept.351st of 402
this lab
most citedleast cited
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