The University of Texas Medical Branch at Galveston · NeuroscienceCNS HIV Research Lab
Eliseo A Eugenin · Galveston, Texas
Research Focus
Dr. Eliseo A. Eugenin's lab at the University of Texas Medical Branch in Galveston focuses on understanding how HIV persists in the central nervous system (CNS) despite antiretroviral therapy. By studying cells like astrocytes and microglia, the lab aims to uncover mechanisms behind viral reservoirs and cellular damage that causes cognitive and motor impairments in individuals living with HIV. Their research seeks to identify new therapeutic strategies to eliminate these viral reservoirs and minimize damage to healthy brain cells.
HIVCNSviral reservoirsastrocytesmicrogliacell communicationantiretroviral therapymetabolismneuroinflammation
Research Aims
4AIM 01Investigate the role of astrocytes in amplifying damage to uninfected cells infected by HIV.
AIM 02Characterize the unique metabolic pathways that enable HIV reservoirs to survive in the CNS.
AIM 03Assess the mechanisms of cell-to-cell communication that lead to bystander damage from HIV-infected cells.
AIM 04Develop therapeutic approaches to target and eliminate HIV reservoirs within myeloid cells in the CNS.
Skills the Lab Values
cell culturein vitro experimentsRNA sequencingflow cytometryWestern blotmicroscopyapoptosis assaysmetabolic profilinggene expression analysis
Output against the department
Publications158top 47% of dept.313th of 671
this lab
most publishedleast published
Citations7.1kbottom 49% of dept.345th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.