Cleveland State University · GeneticsGulshan Inflammation Lab
Kailash Gulshan · Cleveland, Ohio
Research Focus
Dr. Kailash Gulshan's lab focuses on understanding how inflammation related to lipid metabolism contributes to diseases like atherosclerosis and progressive familial intrahepatic cholestasis (PFIC1). The lab investigates the role of specific proteins and metabolic pathways in regulating inflammation and aims to develop new therapeutic strategies for these conditions. By employing advanced techniques, the lab seeks to uncover novel mechanisms that could lead to effective treatments.
atherosclerosisinflammationlipid metabolismPFIC1GsdmDPIP2 traffickingproteomicsanti-atherosclerotic therapies
Research Aims
5AIM 01Investigate the role of ATP8b1 in phosphatidylinositol metabolism and membrane integrity.
AIM 02Determine the mechanistic link between ATP8b1 and inflammation in PFIC1.
AIM 03Evaluate the therapeutic potential of targeting GsdmD in atherosclerosis.
AIM 04Establish the PIP2 flippase activity of ATP8b1.
AIM 05Examine the tissue-specific functions of GsdmD in cardiovascular diseases.
Skills the Lab Values
cell culturemouse modelshigh throughput proteomicsgene editingWestern blotRNA sequencingimmunohistochemistryinflammation assaysbiochemical assays
Output against the department
Publications61bottom 14% of dept.224th of 259
this lab
most publishedleast published
Citations7.7kbottom 42% of dept.149th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.