Yale University · BiologyThe Lipid Immunometabolism Lab
Carlos Fernandez Hernando · New Haven, Connecticut
Research Focus
Dr. Carlos Fernandez Hernando's lab focuses on understanding how lipid metabolism affects immune responses in cardiovascular diseases, particularly atherosclerosis. They study novel enzymes and lipid molecules that help regulate inflammation and cholesterol levels in macrophages, which are immune cells involved in artery health. By investigating these pathways, the lab aims to uncover potential treatments that can improve cardiovascular health by targeting the underlying causes of inflammation and lipid imbalances.
atherosclerosismacrophageimmunometabolismcholesterollipid homeostasisplasma phospholipidsdesmosterolLXRmiRNAcardiometabolic diseases
Research Aims
5AIM 01Investigate the role of lysoplasmalogenases in macrophage responses during atherosclerosis.
AIM 02Determine the effect of DHCR24 deletion on atherosclerosis progression.
AIM 03Evaluate how desmosterol influences macrophage inflammatory response.
AIM 04Assess the therapeutic potential of manipulating lipid metabolism in treating cardiovascular diseases.
AIM 05Elucidate the signaling pathways involved in cholesterol homeostasis and inflammation in cardiovascular health.
Skills the Lab Values
genomicsmetabolomicsmouse modelslipid biochemistrycell cultureflow cytometryanimal surgeryDNA/RNA extractionWestern blottingPCR
Output against the department
Publications235top 26% of dept.269th of 1,033
this lab
most publishedleast published
Citations20ktop 19% of dept.199th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.