UMCUniversity of Massachusetts Chan Medical School · Genetics
Xue Lab
Wen Xue · Worcester, Massachusetts
Research Focus
Dr. Wen Xue's research lab focuses on creating advanced mouse models of cancer using innovative genome editing techniques, specifically prime editing. Their goal is to better understand how genetic mutations contribute to cancer development and treatment resistance. By optimizing tools for precise genetic modifications, the lab aims to produce more accurate cancer models that can help identify effective therapies and biomarkers.
cancer genomicsgenome editingCRISPRmouse modelsprecision medicine
Research Aims
5AIM 01Develop new prime editing tools for generating cancer mouse models.
AIM 02Optimize pegRNA design rules for cancer-associated mutations.
AIM 03Create inducible and floxed alleles in mouse liver using dual-PE approaches.
AIM 04Establish platforms for in vivo cancer modeling using optimized prime editing.
AIM 05Validate driver mutations in liver and lung cancer through novel mouse models.
Skills the Lab Values
prime editingCRISPR/Cas9genomic modificationmouse model generationmolecular cloning
Output against the department
Publications318top 25% of dept.66th of 259
this lab
most publishedleast published
Citations22ktop 27% of dept.69th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.