Duke University · BiologyLin Cancer Lab
Hui-Kuan Lin · Durham, North Carolina
Research Focus
Dr. Hui-Kuan Lin's lab at Duke University focuses on understanding cancer, particularly non-small cell lung cancer (NSCLC) and prostate cancer. The research aims to identify cancer stem cells and their roles in cancer progression and treatment resistance. By developing novel therapeutic strategies that target these unique cell populations, the lab aims to improve treatment outcomes for patients with advanced-stage cancers.
cancer stem cellsnon-small cell lung cancerprostate cancerdrug resistanceimmune evasionmetabolic pathwaystargeted therapyCRISPRoncogenic signalspatient-derived models
Research Aims
5AIM 01Identify novel regulators of cancer stem cells in non-small cell lung cancer.
AIM 02Characterize metabolic pathways involved in prostate cancer progression.
AIM 03Investigate mechanisms of drug resistance in advanced prostate cancer.
AIM 04Develop therapeutic strategies targeting cancer stem cells.
AIM 05Utilize patient-derived models to validate therapeutic targets.
Skills the Lab Values
cell cultureCRISPR/Cas9 gene editingmetabolomicstranscriptomicsmouse modelsimmunotherapy techniquespatient-derived xenograftsbiochemical assaystumor development assaysgene expression analysis
Output against the department
Publications218top 29% of dept.297th of 1,033
this lab
most publishedleast published
Citations15ktop 25% of dept.256th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.