Dartmouth College · BiochemistryCell Growth and Division Laboratory
James B Moseley · Hanover, New Hampshire
Research Focus
Dr. James B Moseley's lab at Dartmouth College studies how cells control their size and shape, focusing on basic cellular mechanisms that can contribute to diseases like cancer. By using fission yeast as a model organism, the lab explores the processes involved in cell growth and division. Their interdisciplinary approach combines genetics and various microscopy techniques to uncover important signals that regulate these fundamental biological functions.
cell sizecell shapefission yeastmitosiscell growthsignal transductiongenetic screeningbiochemical pathwayscancer research
Research Aims
4AIM 01Define the molecular mechanisms controlling cell size at division.
AIM 02Investigate the role of cell cycle pathways in monitoring cell size.
AIM 03Explore how cell polarity influences cell shape.
AIM 04Identify how cell size and shape affect spatial patterning of cellular components.
Skills the Lab Values
genetic manipulationlive-cell microscopyphosphoproteomicsbiochemical reconstitutionquantitative modelingcell culturedata analysis in biologyfluorescence microscopyprotein purification
Output against the department
Publications78bottom 16% of dept.338th of 402
this lab
most publishedleast published
Citations4.5kbottom 26% of dept.299th of 402
this lab
most citedleast cited
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