RUThe Rockefeller University · Microbiology & Immunology
Victora Immunology Lab
Gabriel D Victora · New York, New York
Research Focus
The research lab of Gabriel D Victora at Rockefeller University focuses on understanding how the immune system, particularly B cells, generates antibodies to fight infections and diseases. Their work investigates the mechanisms behind antibody production in the gut, how B cells select specific microbial targets, and how this process contributes to health and disease, such as inflammatory bowel disease and cancer. The lab employs advanced experimental techniques to map the complexities of immune responses, aiming to improve vaccine design and therapeutic strategies.
B cellsantibody responsegerminal centersIgAintestinal microbiotaaffinity maturationimmunologyT cell helpadaptive immunity
Research Aims
5AIM 01Understand the role of T cell help in B cell selection in germinal centers.
AIM 02Characterize the specificity of B cells in the gut-associated lymphoid tissue.
AIM 03Investigate the molecular mechanisms of antibody evolution during immune responses.
AIM 04Map the interactions between B cells and microbiota in the intestinal environment.
AIM 05Determine how B cell receptor dynamics influence antibody affinity maturation.
Skills the Lab Values
B cell fate mappingsingle-cell sequencinggenetically-engineered mouse modelsflow cytometrycell culturephage display techniquesmicroscopyantibody affinity assaysbioinformatics
Output against the department
Publications152top 43% of dept.208th of 486
this lab
most publishedleast published
Citations18ktop 22% of dept.107th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.