New York University · BiologyT Cell Immunotherapy Research Unit
Michelle Krogsgaard · New York, New York
Research Focus
Dr. Michelle Krogsgaard's lab focuses on enhancing the effectiveness of T cell-based immunotherapies for cancer treatment. By studying the signaling pathways of T cell receptors, the lab aims to improve the ability of T cells to recognize and kill tumor cells without compromising their specificity. This research holds promise for developing better strategies in cancer immunotherapy, particularly for melanoma.
immunotherapyT cell receptorcancertumor killingsignal transduction
Research Aims
3AIM 01Identify signal-enhancing TCR mutants to improve tumor recognition by T cells.
AIM 02Explore mechanisms that influence TCR-CD3 signaling and tumor response.
AIM 03Evaluate tumor killing efficacy of engineered T cells in vitro and in vivo.
Skills the Lab Values
T cell culturemutagenesisin vitro assaysflow cytometrymolecular cloning
Output against the department
Publications161top 42% of dept.429th of 1,033
this lab
most publishedleast published
Citations5.3kbottom 39% of dept.625th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.