University of Michigan-Ann Arbor · Biomedical EngineeringMicrobial Cancer Therapeutics Lab
Jiahe Li · Ann Arbor, Michigan
Research Focus
Dr. Jiahe Li's lab focuses on developing innovative microbial-based treatments for colorectal cancer, specifically targeting harmful metabolites produced by gut bacteria. They aim to understand how engineered non-pathogenic bacteria can neutralize a carcinogenic substance called colibactin, which is linked to cancer progression. The research combines microbiology with cancer biology to explore new therapeutic strategies for combating this disease.
colorectal cancermicrobial therapiescolibactinbacterial metabolitesengineered probiotics
Research Aims
4AIM 01Develop an enzyme to inhibit colibactin production in gut bacteria.
AIM 02Investigate how engineered E. coli can outcompete harmful bacteria in the gut.
AIM 03Explore the impact of ClbS-displaying E. coli on tumor progression in colorectal cancer models.
AIM 04Understand the molecular mechanisms of colibactin-induced DNA damage in intestinal cells.
Skills the Lab Values
bacterial culturegenetic engineeringprotein expressionmouse modelstumorigenesis assaysimmunotherapy techniquesDNA mutational analysismolecular cloningbiochemical assays
Output against the department
Publications132bottom 27% of dept.432nd of 595
this lab
most publishedleast published
Citations3.1kbottom 23% of dept.458th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.