University of Alabama at Birmingham · BiologyThe Vascular Insight Lab
Vivek Nanda · Birmingham, Alabama
Research Focus
Dr. Vivek Nanda's research lab at the University of Alabama at Birmingham focuses on understanding the molecular mechanisms behind peripheral artery disease (PAD), a serious cardiovascular condition. The lab investigates a specific gene, Leiomodin 1, to explore its role in the formation of mature blood vessels, which is crucial for restoring blood flow in patients with PAD. By studying the effects of this gene on smooth muscle cells, the lab aims to develop strategies and therapies that could improve treatment outcomes for individuals suffering from PAD.
Leiomodin 1Peripheral artery diseaseMature blood vesselsSmooth muscle cellsCardiovascular disease
Research Aims
3AIM 01Investigate the mechanisms by which reduced LMOD1 impairs neovessel maturation in PAD.
AIM 02Evaluate the role of smooth muscle cells in LMOD1-mediated defects in neovessel development.
AIM 03Examine the implications of LMOD1 in neovessel maturation relating to type 2 diabetes and its association with PAD.
Skills the Lab Values
Cell cultureGenomic techniquesMouse modelsIn vivo surgeryQuantitative PCRMolecular biology techniquesTranslational researchCoculture techniquesSignal transduction analysisData collection and reporting
Output against the department
Publications56bottom 14% of dept.890th of 1,033
this lab
most publishedleast published
Citations2.3kbottom 16% of dept.870th of 1,033
this lab
most citedleast cited
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